Here is some javascript that might get you started in the right direction. Below is code that stops a user from pressing the ENTER key on the entire document (document.onkeypress). You could modify this to block any key you like by changing the keyCode == <value> to the desired key, in your case backspace and delete.
You would need to attach this javascript to the onkeypress event of each RadComboBox that requires these inputs to be blocked.
Sorry I don't have time to build a solution and test it, but this should work.