Since I do not have your code I am not able to find the reason for the problem.
In case you ajaxify the button by wrapping it into an Update Panel, please make sure that you have set its UpdateMode
property to Conditional
In case you use the RadAjaxManager control, your project should work fine.
In case your problem persists, please open a new support ticket and send a simple, fully runnable (including DB) project which reproduces the problem. Once I receive it I will do my best to help.
the Telerik team