Can you make a grid like at Group By Expressions sample at RadControls for Asp.Net AJAX, but where every column would contain sum amount calculated from cells below it?
You can refer to the following help document to understand how to add aggregations to the group expressions so that the group headers in the grid display the sum values for columns: Performing calculations in group header
A better suggestion would be to use the GroupFooters to display the sum for each set of grouped rows as demonstrated in the demo below. You just have to set the ShowGroupFooter property to true and set the Aggregate property for each column to Sum. Group Footers