We are aware of an IIS known issue for IE10 that might be related to the unwanted behavior you are experiencing on your site. There is a patch provided by Microsoft that is necessary to be applied to the server to solve it.
For .NET 4.0 check this one: http://support.microsoft.com/kb/2600088
For .NET 2.0:
http://support.microsoft.com/kb/2600100 for Win7 SP1/Windows Server 2008 R2 SP1, Windows Vista/Server 2008, Windows XP/Server 2003
http://support.microsoft.com/kb/2608565 for Win7/Windows Server 2008 R2 RTM
You could find more information at various places on the internet like:
If the listed approach doesn't help you to resolve the problem I would advise you to try to isolate the issue in a simple, fully runnable project
and send it back so that we will be able to reproduce and examine it locally.
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