What is the best architecture for building a .NET v.4.0 with Telerik RadControls Q3 2010 website that may also support a native mobile app in the future.

[kd]

Hi all,
I am building a new web site over RadControls . the website is a transactional web  application  where users login and perform operation. for right now the site will be accessable common desktop browsers and later version of application will be implement for mobile.So question is that what is the best way to design the system to support that?
Here is what i am thinking ! i am thinking to develop a 3 tier application with sql server database,
can any one please tell me which is the best architecture for RadCotrols and send me a sample code.

Thanks
Regards
kd