I already answered your support thread and you can find information about the validators there.
As to the reference of the tooltip from code behind, what I noticed is that your code is actually executed too early, before the tooltip's client object is created.
The controls in the RadControls for ASP.NET AJAX suite are built upon the MS AJAX framework and the framework itself creates its controls (including RadToolTip) in the Sys.Application.add_init() method.
Here is how the client events are fired in the page life cycle:
window.onload -> Sys.Application.init -> Sys.Application.load
You can see that the client object representation of MS AJAX controls are created just as the last code on the page in the Sys.Application.init event, which is raised after the window.onload event.
That is why when you call your code in window.onload by registering the client script, the RadToolTip will still not be created on the page and you will get an error. To avoid this problem, you can either execute your code with a small timeout, or use the Sys.Application.add_load method.
the Telerik team