<ExceptionType>System.NullReferenceException, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</ExceptionType>
<Message>Object reference not set to an instance of an object.</Message>
<Source>mscorlib</Source>
<StackTrace> at System.Reflection.RuntimeAssembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)
at System.Reflection.RuntimeAssembly.InternalGetSatelliteAssembly(String name, CultureInfo culture, Version version, Boolean throwOnFileNotFound, StackCrawlMark& stackMark)
at System.Resources.ManifestBasedResourceGroveler.GetSatelliteAssembly(CultureInfo lookForCulture, StackCrawlMark& stackMark)
at System.Resources.ManifestBasedResourceGroveler.GrovelForResourceSet(CultureInfo culture, Dictionary`2 localResourceSets, Boolean tryParents, Boolean createIfNotExists, StackCrawlMark& stackMark)
at System.Resources.ResourceManager.InternalGetResourceSet(CultureInfo requestedCulture, Boolean createIfNotExists, Boolean tryParents, StackCrawlMark& stackMark)
at System.Resources.ResourceManager.InternalGetResourceSet(CultureInfo culture, Boolean createIfNotExists, Boolean tryParents)
at System.Resources.ResourceManager.GetString(String name, CultureInfo culture)
at Telerik.Web.LocalizationProvider.EmbeddedResourceLocator.GetString(String resourceKey)
at Telerik.Web.LocalizationStrings.GetString(String key, Boolean throwErrorIfMissing)</StackTrace>
web.config httphandlers has following entries with regards to telerik
<httpHandlers>
<add path="Telerik.RadUploadProgressHandler.ashx" verb="*" type="Telerik.Web.UI.RadUploadProgressHandler, Telerik.Web.UI" />
<add path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler, Telerik.Web.UI" validate="false" />
<add path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="ArcherTech.Web.HttpHandlers.ArcherDialogHandler, ArcherTech.Web" validate="false" />
<add path="Telerik.Web.UI.WebResource.axd" verb="*" type="Telerik.Web.UI.WebResource, Telerik.Web.UI" validate="false" />
The issue comes intermittently while access WebApp, needs IIS restarts and works fine for sometime until running into same issue again later.