Binding RadGrid at runtime is straightforward. Just assign the given data to the grid's DataSource property and call its Rebind() method. If the column fields in your dataset vary, you might as well set AutoGeneratedColumns=true for the grid. To edit/update/insert items into the underlying data-source, attach event handlers to the corresponding grid commands and handler the operations manually as explained in the related topic:
Hope it helps.
the Telerik team
Do you want to have your say when we set our development plans? Do you want to know when a feature you care about is added or when a bug fixed? Explore the Telerik Public Issue Tracking
system and vote to affect the priority of the items