I am using panel in RadToolTip. I have command button "btnOpen" on RadGrid. Whenever "btnOpen" is clicked it shows RadToolTip for specific row in RadGrid. Its all Working fine but not showing loading panel. <telerik:RadAjaxManager ID="RadAjaxManager1" runat="server"> <ClientEvents OnRequestStart="RequestStart" OnResponseEnd="ResponseEnd" /> <AjaxSettings> <telerik:AjaxSetting AjaxControlID="btnOpen"> <UpdatedControls> <telerik:AjaxUpdatedControl ControlID="RadToolTip1" LoadingPanelID="RadAjaxLoadingPanel1" /> <telerik:AjaxUpdatedControl ControlID="Panel1" LoadingPanelID="RadAjaxLoadingPanel1" /> </UpdatedControls> </telerik:AjaxSetting> <telerik:AjaxSetting AjaxControlID="rgCity"> <UpdatedControls> <telerik:AjaxUpdatedControl ControlID="RadToolTip1" LoadingPanelID="RadAjaxLoadingPanel1" /> <telerik:AjaxUpdatedControl ControlID="Panel1" LoadingPanelID="RadAjaxLoadingPanel1" /> </UpdatedControls> </telerik:AjaxSetting> </AjaxSettings> </telerik:RadAjaxManager> <telerik:RadAjaxLoadingPanel ID="RadAjaxLoadingPanel1" runat="server"></telerik:RadAjaxLoadingPanel> <telerik:RadToolTip ID="RadToolTip1" Animation="Slide" AnimationDuration="190" runat="server" Modal="true" HideEvent="ManualClose" Style="z-index: 6990" BackColor="White" Position="Center" Width="729px" Height="200px"> <asp:Panel ID="Panel1" BackColor="Pink" runat="server" Height="190px"> <table align="center"> <tr> <td> <asp:Label ID="lbl_id" Text="City ID" runat="server"></asp:Label> <asp:TextBox ID="Txt_id" runat="server"></asp:TextBox> </td> </tr> <tr> <td> <telerik:RadAsyncUpload runat="server" ID="FileUpload1" MultipleFileSelection="Disabled"> </telerik:RadAsyncUpload> </td> </tr> <tr> <td> <telerik:RadButton runat="server" Skin="Silk" ID="BtnSubmit" Text="Upload files" OnClick="BtnSubmit_Click"></telerik:RadButton> <asp:Label ID="lable_res" runat="server"></asp:Label> </td> </tr> </table> <%--<telerik:RadFormDecorator ID="rfd1" runat="server" DecoratedControls="all"></telerik:RadFormDecorator>--%> </asp:Panel> </telerik:RadToolTip>