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Disable Plugins
When setting DisablePlugins property to true RadAsyncUpload does not use either Silverlight or Flash modules to upload files. With DisablePlugins property set to true the RadAsyncUpload uses File API (if the browser supports it) or the IFrame module. You can set the DisablePlugins property through mark up or in the code-behind.
The DisablePlugins property is available As of Q3 2011.
Here is how you can set the property in the markup of your page:
ASP.NET
<telerik:RadAsyncUpload RenderMode="Lightweight" runat="server" ID="RadAsyncUpload1" DisablePlugins="true"></telerik:RadAsyncUpload>