Controls Not Compatible with RadAjax
The following ASP.NET controls are not compatible with partial-page updates, and are therefore not supported inside anUpdatePanel control:
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Web Parts controls. For more information, see ASP.NET Web Parts Controls.
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FileUpload controls when they are used to upload files as part of an asynchronous postback.
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GridView and DetailsView controls when their EnableSortingAndPagingCallbacks property is set to true . The default is false .
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Login, PasswordRecovery, ChangePassword, and CreateUserWizard controls whose contents have not been converted to editable templates.
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The Substitution control.
See a full list of controls that are not compatible with RadAjax for ASP.NET AJAX from the official Microsoft AJAX documentation here (scroll about halfway down the article.)).