I have a RadToolTipManager and a RadGrid inside of an ASP.NET AJAX UpdatePanel, and I'm having two problems:

1)  AutoTooltipify = False is not honored on an async postback, but does work on a full postback.  I'm working around this for now by adding a dummy item to the TargetControls.

2)  I have AutoCloseDelay set to 10000 (10 seconds).  In IE 7, the tooltip does not close after 10 seconds (only when I move the mouse away).  It works fine in Opera, FireFox, and Safari.

Hello mlandauer,
I created a simple page to test your scenario, but could not reproduce the problem - please find it attached. As soon as you change the pageIndex of the RadGrid, the TargetControls collection of the RadToolTipManager becomes empty, but none of the elements on the page gets tooltipified. My tooltips close after 10 seconds in IE7 as well.  

Please make sure that you are using the latest version of the RadControls for ASP.NET AJAX suite, and in case the problem persists, we will need a simple running application, demonstrating the problem, so that we can research on our side what is causing it.

Greetings,
Tsvetie
the Telerik team