RadUpload can be used for uploading image files which could be saved in a database using the server-side API which the upload control provides. UploadedFile's InputStream
property can be used for accessing the content of the corresponding uploaded file without the need of saving the file to a temporary location. Please, refer to the Manipulating the Uploaded Files help article
for more details on how to implement the desired functionality and a sample code snippet demonstrating a similar scenario.
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All the best,
the Telerik team