I changed the property with the value you said in the last post, but I obtained the same problem. I just changed TargetPhysicalFolder property for UNC path as you can see below:
|RadUpload1.TargetPhysicalFolder = @"\\192.168.0.4\c$\Files\Upload";
|foreach (UploadedFile validFile in RadUpload1.UploadedFiles)
| string targetFolder = Server.MapPath("~/Arq");
| validFile.SaveAs(Path.Combine(targetFolder, "UploadTest.pdf"), true);
It's an example. The path of virtual directory (Arq) is Z:\Upload.
Is there anything I need to set to achieve my goal besides this example?