On first look the Shinu's solution will work perfectly client side. You will need to validate the values server side also. You can do this by checking the .Text property of RadTextBox manually, or still use asp:Validator for this purpose.
If you want to get updates on new releases, tips and tricks and sneak peeks at our product labs directly from the developers working on the RadControls for ASP.NET AJAX, subscribe to their blog feed now.