I have run into an issue I was wondering if someone can help me out or let me know if it's not possible. I have built a dynamic RadGrid on a page that needs to be Excel like with all of the rows to be in edit mode. I have set the grid's MasterTableView.EditMode to InPlace and on binding I loop through and add all the EditIndexs for the rows. This works and I have a nice grid with textboxes. What I'm struggling with is that when a user updates a cell and then moves off of the row we would like to update that row via a web service call from the code behind. Is there an easy way to do this? Without a post back being triggered the only thing I can think of is to use javascript. Any helpful advice would be appreciated.