You can create your own custom skin for radGrid in the Theme Builder
as explained in the documentation https://docs.telerik.com/devtools/aspnet-ajax/theme-builder/overview
Once you do that copy the generated css files in the App_Themes or another folder and import them on the page with the grid you want to customize.
Set the Skin property with the name of the custom skin and the EnableEmbeddedSkins property of this grid to false:
<telerik:RadGrid ID="RadGrid1" Skin="RedLimeSkin" EnableEmbeddedSkins="false" RenderMode="Lightweight" ...
The set the Skin property of the other grids on the page to one of the available built-in skins:
<telerik:RadGrid ID="RadGrid2" runat="server" RenderMode="Lightweight" Skin="Bootstrap" ...
Make sure that the RenderMode properties of all grids are set to Lightweight.
For your convenience I recorded and attached a sample video demo.
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