I can ensure you that the RadControls fully support the MVVM pattern. For more information about implementing RadDocking control with MEF and Prism 4.0, please refer to the following forum thread - http://www.telerik.com/community/forums/wpf/docking/raddocking-with-prism-4-mvvm-mefbootstrapper.aspx
Hope this helps.
All the best,
the Telerik team
Explore the entire Telerik portfolio by downloading the Ultimate Collection trial package. Get it now >>