When there is no item in RadComboBox i did't want check all option.
<telerik:RadComboBox ID="RadComboBoxSites" runat="server" OnClientItemChecking="OnClientItemChecking" CheckBoxes="true" EnableCheckAllItemsCheckBox="true" DataTextField="SiteName" DataValueField="SiteUid" AppendDataBoundItems="true" OnItemDataBound="RadComboBoxSites_ItemDataBound" DropDownWidth="250px"OnClientDropDownOpening="disableComboBoxSeparator;disableCheckall" EmptyMessage="Please select a site..." MaxHeight="192px"></telerik:RadComboBox>