We are facing this issue currently in chrome browser wherein, whenever the font-size/font-family is changed from dropdown, it is not reflected for the text we enter thereafter rather penultimate font-size/font-family is considered. This works fine whenever we select the text first and apply the changes.
To add to this, we have recently upgraded to Telerik ASP.Net Editor v.2015.2.729.45. This seems to be common issue across community, but none of the proposed solutions worked for us.
Also, same issue is reproduced at http://demos.telerik.com/aspnet-ajax/editor/examples/overview/defaultcs.aspx demo page.
Can you please look into this issue?