Instead of using just one table to bring back some data (see the following):

http://demos.telerik.com/aspnet-ajax/grid/examples/databinding/net35datasourcecontrols/defaultcs.aspx

is it possible to generate a LINQ query based on multiple entities to bring back the data?

Otherwise, just the one table is good fro DropDowns, but not for querying data against multiple entities and having it come back into the grid.

Hello,

 Yes, it is possible. The databinding in the grid does not depend on how exactly you retrieve the data, whether it's from one or multiple tables. You can simply pass the LINQ query or a collection of objects and it will bind to the returned result.
If you are using LinqDataSource or EntityDataSource you can use their Selecting event to preform a more complex LINQ query as shown here.
Again the actual approach of retrieving the data is completely irrelevant to the databinding in the grid.

Regards,
Marin
Telerik