Please do me favor one thing.
Now,I'm facing the following error.
Could not load file or assembly 'Telerik.Web.UI, Version=2011.1.413.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4' or one of its dependencies. The located assembly's manifest definition does not match the assembly reference.
<add path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI, Version=2011.1.413.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4" validate="false"/>
Thanks in advance....
7 Answers, 1 is accepted

I need to know answer urgent.You have not yet replied after two days I asked..
After I changed Telerik licensed dll,that error comes out.
Which assembly version should I need to change???

If you are upgrading from 2011.1.413.40 to latest, you will probably need to update the version in the handler registration as well:
<add path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI, Version=2011.2 712.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4" validate="false"/>
Greetings,
Bart.

There's still have error and when I tried the following one,it does work.But I'm not sure it's the correct way or not.
<add path="ChartImage.axd" type="Telerik.Web.UI.ChartHttpHandler" verb="*" validate="false" />
Anyway,Thanks for your reply.

Can you post your web.config here? Have you updated both http handlers in the system.web and the system.webServer sections there? Check this help article for more info: http://www.telerik.com/help/aspnet-ajax/introduction-registering-the-httphandlers-on-windows-vista-iis-7-integrated-mode.html.
Greetings,
Bart.

Please check the following codes.
Thanks.
The following code does work.Yellow colour helighted.
<?xml version="1.0"?>
<configuration>
<connectionStrings>
</connectionStrings>
<appSettings>
</appSettings>
<system.web>
<anonymousIdentification enabled="true"/>
<profile enabled="true">
<properties>
<add name="SCart" serializeAs="Binary" type="FP.IPS.Business.Entities.Cart" allowAnonymous="true"/>
</properties>
</profile>
<compilation debug="true" targetFramework="4.0">
<assemblies>
<add assembly="System.Design, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B03F5F7F11D50A3A"/>
<add assembly="System.Windows.Forms, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B77A5C561934E089"/>
<add assembly="System.Data.Linq, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B77A5C561934E089"/>
</assemblies>
</compilation>
<httpHandlers>
<add path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="HelpDesk.SessionStateDialogHandler" validate="false"/>
<add path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler" validate="false"/>
<add path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource" verb="*" validate="false"/>
<add path="ChartImage.axd" type="Telerik.Web.UI.ChartHttpHandler" verb="*" validate="false" />
</httpHandlers>
<httpModules>
<add name="RadCompression" type="Telerik.Web.UI.RadCompression"/>
</httpModules>
<pages clientIDMode="AutoID"/>
</system.web>
<system.webServer>
<validation validateIntegratedModeConfiguration="false"/>
<modules>
<add name="RadCompression" type="Telerik.Web.UI.RadCompression"/>
</modules>
<handlers>
<add name="Telerik.Web.UI.SpellCheckHandler.axd_*" path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler" preCondition="integratedMode,runtimeVersionv2.0"/>
<add name="Telerik.Web.UI.DialogHandler.aspx_*" path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="HelpDesk.SessionStateDialogHandler" preCondition="integratedMode,runtimeVersionv2.0"/>
<add name="Telerik_Web_UI_WebResource_axd" verb="*" preCondition="integratedMode" path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource"/>
</handlers>
</system.webServer>
</configuration>
--------------------------------------****--------------------------------
The following codes cause this error.
Parser Error Message: The given assembly name or codebase was invalid. (Exception from HRESULT: 0x80131047)
Line 61: <add path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI, Version=2011.2 712.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4" validate="false"/>
<?xml version="1.0"?>
<configuration>
<connectionStrings>
</connectionStrings>
<appSettings>
</appSettings>
<system.web>
<!--
Set compilation debug="true" to insert debugging
symbols into the compiled page. Because this
affects performance, set this value to true only
during development.
-->
<anonymousIdentification enabled="true"/>
<profile enabled="true">
<properties>
<add name="SCart" serializeAs="Binary" type="FP.IPS.Business.Entities.Cart" allowAnonymous="true"/>
</properties>
</profile>
<compilation debug="true" targetFramework="4.0">
<assemblies>
<add assembly="System.Design, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B03F5F7F11D50A3A"/>
<add assembly="System.Windows.Forms, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B77A5C561934E089"/>
<add assembly="System.Data.Linq, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B77A5C561934E089"/>
</assemblies>
</compilation>
<httpHandlers>
<add path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="HelpDesk.SessionStateDialogHandler" validate="false"/>
<add path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler" validate="false"/>
<add path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource" verb="*" validate="false"/>
<add path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI, Version=2011.2 712.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4" validate="false"/>
</httpHandlers>
<httpModules>
<add name="RadCompression" type="Telerik.Web.UI.RadCompression"/>
</httpModules>
<pages clientIDMode="AutoID"/>
</system.web>
<system.webServer>
<validation validateIntegratedModeConfiguration="false"/>
<modules>
<add name="RadCompression" type="Telerik.Web.UI.RadCompression"/>
</modules>
<handlers>
<add name="Telerik.Web.UI.SpellCheckHandler.axd_*" path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler" preCondition="integratedMode,runtimeVersionv2.0"/>
<add name="Telerik.Web.UI.DialogHandler.aspx_*" path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="HelpDesk.SessionStateDialogHandler" preCondition="integratedMode,runtimeVersionv2.0"/>
<add name="Telerik_Web_UI_WebResource_axd" verb="*" preCondition="integratedMode" path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource"/>
<add name="ChartImage.axd" path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI, Version=2011.2 712.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4"/>
</handlers>
</system.webServer>
</configuration>
----------------------------------------********----------------------------------------------
The following codes cause this error.
The resource cannot be found.
<?xml version="1.0"?>
<configuration>
<connectionStrings>
</connectionStrings>
<appSettings>
</appSettings>
<system.web>
<!--
Set compilation debug="true" to insert debugging
symbols into the compiled page. Because this
affects performance, set this value to true only
during development.
-->
<anonymousIdentification enabled="true"/>
<profile enabled="true">
<properties>
<add name="SCart" serializeAs="Binary" type="FP.IPS.Business.Entities.Cart" allowAnonymous="true"/>
</properties>
</profile>
<compilation debug="true" targetFramework="4.0">
<assemblies>
<add assembly="System.Design, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B03F5F7F11D50A3A"/>
<add assembly="System.Windows.Forms, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B77A5C561934E089"/>
<add assembly="System.Data.Linq, Version=4.0.0.0, Culture=neutral, PublicKeyToken=B77A5C561934E089"/>
</assemblies>
</compilation>
<httpHandlers>
<add path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="HelpDesk.SessionStateDialogHandler" validate="false"/>
<add path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler" validate="false"/>
<add path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource" verb="*" validate="false"/>
</httpHandlers>
<httpModules>
<add name="RadCompression" type="Telerik.Web.UI.RadCompression"/>
</httpModules>
<pages clientIDMode="AutoID"/>
</system.web>
<system.webServer>
<validation validateIntegratedModeConfiguration="false"/>
<modules>
<add name="RadCompression" type="Telerik.Web.UI.RadCompression"/>
</modules>
<handlers>
<add name="Telerik.Web.UI.SpellCheckHandler.axd_*" path="Telerik.Web.UI.SpellCheckHandler.axd" verb="*" type="Telerik.Web.UI.SpellCheckHandler" preCondition="integratedMode,runtimeVersionv2.0"/>
<add name="Telerik.Web.UI.DialogHandler.aspx_*" path="Telerik.Web.UI.DialogHandler.aspx" verb="*" type="HelpDesk.SessionStateDialogHandler" preCondition="integratedMode,runtimeVersionv2.0"/>
<add name="Telerik_Web_UI_WebResource_axd" verb="*" preCondition="integratedMode" path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource"/>
<add name="ChartImage.axd" path="ChartImage.axd" verb="*" type="Telerik.Web.UI.ChartHttpHandler, Telerik.Web.UI, Version=2011.2 712.40, Culture=neutral, PublicKeyToken=121fae78165ba3d4"/>
</handlers>
</system.webServer>
</configuration>
We reviewed the attached web.config files and we were able to correctly load the chart with the first one as soon as we added the necessary http handler registration in the webServer section of the web.config (see the attached sample application and the help topic Bart mentioned here).
As for the rest of your web.config snippets -- it seems there is a missing dot (".") in the version string (Version=2011.2.712.40) and probably this triggers the more cryptic errors.
Kind regards,
Giuseppe
the Telerik team

I use radgrid, and after upgrading it, it still worked on my deploy machine, but no longer in the test environment!
After a LONG time of searching and implementing many suggestions, I found that on my productive/test environment, IIS7 was running in Classic mode. Switching it to Integrated and my "RadGrid-Portal" worked immediately.