Hello Amanda Hayden,
You can handle the OnClientSelectedIndexChanged event of the RadComboBox and initiate an AJAX request as described in
this help article.
I prepared a small example for you based on
this online demo - please find it attached.
The scenario that this sample demonstrates is very simple - there is a RadComboBox in a user control that updates RadGrid.
I hope this helps.
Regards,
Kalina
the Telerik team
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