We seem to have a very similar issue to the one reported here:
Q2 2010 (Version 2011.2.713)
Problem: RadAsyncUpload sometimes fail to upload the files to the target folder.
except the version we are using is 2013.1.417.45 in which the issue is supposed to be fixed. The challenge is that the problem is not consistent. We're able to upload video files usually without a problem but at the same time we have many users, dozens a day, that get an error during the postback portion of the upload when the temporary file is not found. We tried using the custom handler fix as described in that earlier version problem solution but that doesn't seem to affect the issue. The users seem to be using a variety of browsers and systems so we haven't been able to isolate a pattern.
We'd even be okay not having the temporary files delete at all and we'll manually delete them daily if that is possible.
Is there any potential solution to this?
thanks
10 Answers, 1 is accepted

To add to this post, the error message we are getting on the postback - not all the time but consistently enough that it is a major problem - is:
Error Type: System.IO.FileNotFoundException: Could not find file 'C:\inetpub\wwwroot\​xxxxxxxxx\xxxxxxxxx\App_Data\RadUploadTemp\1eqovf1u.csl​

Please read this post:
http://www.telerik.com/forums/saveas-throws-error-as-temporary-file-has-been-moved-to-target-folder-already#-hcZNMe5SU6BF8ZTKhdycg
Regards,
Hristo Valyavicharski
Telerik

You could do the following. Create a custom handler which inherits ours and override the following method AddCacheDependency to do nothing. This way you will prevent the adding of the files in the cache for further deletion. Keep in mind that you will need to delete the temp files with other mechanism.
Regards,
Peter Filipov
Telerik


Please review the attached project and let me know if it works for your case.
Regards,
Peter Filipov
Telerik

The handler should be working fine and it does not require any registrations in the web.config. My suggestion is that something is blocking the request. Could you test the sample on other machine?
Regards,
Peter Filipov
Telerik