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<div id="spreadsheet"></div>
<script type="text/javascript" charset="utf-8">
    $("#spreadsheet").kendoSpreadsheet();
    var spreadsheet = $("#spreadsheet").data("kendoSpreadsheet");
    var sheet = spreadsheet.activeSheet();
    sheet.range("A1").value("50px");
    sheet.range("A1").fontSize(50);
</script>

FontSize

fontSize