Hello Victor Campos,
When RadScriptManager combines scripts it puts the version of the assembly in which they are embedded in the URL. So when the assembly version is updated the URL is changed and the script resources are requested by the browser again instead of being taken from its cache.
Can you confirm that the version of your assembly changed across updates? If your case is different, can you provide more details about the URL which cannot be refreshed? What is the exact URL?
the Telerik team