Hi Daryl,
You can accomplish this, with defining your own custom logic that will update (either through bindings, or manually) the business object properties since this cannot be integrated in the default Edditing mechanism of RadGridView.
You can open the Popup on MouseLeftButtonDown/Up for RadGridView. You can get the cell that has been the source of the mouse event by using the e.OriginalSource property.
Hope this helps.
Regards,
Nik
Telerik
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