Telerik Reporting can connect to virtually any database through ADO.NET data adapter or OleDB/ODBC connections. Even better, in case you don't have such driver at hand, we got you covered - our product ships with a set of ODBC drivers, provided by DataDirect, allowing you to connect to some of the most popular databases. The driver set includes IBM DB2, so although we haven't tested this specific scenario, there shouldn't be any problem connecting the report to that database.
I would suggest to go through the Getting Started articles that show how to design your report and connect it to data. Should you have further questions, please do not hesitate to ask.
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