Please check the attached demo project that illustrates a report that is created in VS, its report parameters are removed and respectively unreferenced data source components are not serialized in the final TRDP file. The project uses Telerik Reporting R3 2016 that can be changed by using the Upgrade Wizard
The idea is that you need to remove all references to the data source component to avoid serializing it at the end.
If you need further help, please modify the project to illustrate the problem and send it back to us in a support ticket, or let us know the changes via code snippets here.
Telerik by Progress
Do you want to have your say when we set our development plans?
Do you want to know when a feature you care about is added or when a bug fixed?
Telerik Feedback Portal
and vote to affect the priority of the items