Hello John,
Could you please elaborate what exactly is the issue you are facing in ajaxifying the controls in your Web Part? I would suggest you to follow the instructions provided in the forum post below and verify if they work for you:
http://www.telerik.com/community/forums/sharepoint-2010/integrate-ajax-controls/telerik-ajax-issue-with-sharepoint-2010.aspx
Regards,
Maria Ilieva
Telerik
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