Any database having a valid .NET data provider for it can be used with the SqlDataSource component. The SqlDataSource component uses the .NET data provider to know how to recognize SQL parameters and what classes should be used for creating a connection and getting data.
For more details, check SqlDataSource Component.
You can create a custom data access layer and consume it through the other available data source components e.g. EntityDatasource, ObjectDataSource, OpenAccessDataSource.
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