Generally, when RadGridView loses focus it will invoke the CommitEdit operation if there is a row in edit mode. This is the default behavior and it is controlled by the ActionOnLostFocus property of the RadGridView (its default value is CommitEdit). Can you please check if this property is properly set to your grid? If this is not the case, please let me know and I will be happy to assist you further.
Please keep in mind that this will happen only if the GridView loses the focus, not the cell. This is by design because the commit operation is executed for the data item which is represented by the whole GridVIewRow. This design allows you to edit a cell, move to the next cell and edit it, and so on.
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