I know that the ComboBoxColumn doesn't expose a SelectionChanged event but I want to be able to handle this type of behaviour. I have a ComboBoxColumn with its ItemsSource bound to an OberservableCollection and its DataMemberBinding set to a property of the same type. When I change its selection I want to take an action; specifically, I want to set the value of another property to a value I determine in my . I want to use MVVM, so I don't want to add a handler to the grid in .