You can specify whether the search functionality is enabled for a given column by setting the column's AllowSearching property to false as shown below:
this.radGridView1.Columns["LastName"].AllowSearching = false;
this.radGridView1.Columns["FirstName"].AllowSearching = false;
I hope this helps. Should you have any other questions, I will be glad to help.
Get quickly onboarded and successful
with your Telerik and/or Kendo UI products with the Virtual Classroom free technical training, available to all active customers. Learn More.