Our controls, although written in C#, can be used in VB applications as well. The framework allows this and you should not have any problems. To get started, please review the examples which come with the installation. At the top of the example you will find VB code snippets as well.
You can also review the provided documentation - I am sure it will help you with your first project. The online version of the docs can be found here: http://www.telerik.com/products/winforms/documentation.aspx
the Telerik team