According to the provided information, it seems that you would like to modify the existing Fluent theme via the Visual Style Builder.
In the Fluent theme, this ripple effect is introduced by EnableHighlight and EnableBorderHighlight properties and they are set on element level, not global. This means that if you want to disable this highlighting effect you should go through all the elements that you want to modify and disable it as shown in the attached picture.
After modifying the theme you can save it and apply it in your application. Plese refer to the following article: https://docs.telerik.com/devtools/winforms/styling-and-appearance/using-custom-themes
I hope this information is useful. If you have other questions please let me know.
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