Using Safari 15.0 visit the documentation page for the DropDownList (https://www.telerik.com/kendo-vue-ui/components/dropdowns/).
Try the examples and you will find that it's not possible to change items in the ComboBox (after the 1st selection). Also it is not possible to choose an item in the DropDownList.
Have confirmed this behaviour is consistent with behaviour we're experiencing in our application.
Impacts both mobile and desktop Safari versions.