When you enable disable RadGridView, GridViewRow, GridViewColumn, GridViewCell you perform this logic on a cell level. Indeed when you disable the whole grid, a gray border appeared and mouseover/selection effects are lost. If you want to maintain these effects you should predefine the template of GridViewCell and modify the Border element named Background_Disabled.
You should change its background color to a color, which allows transparency.
the Telerik team
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