I haven't personally used MVC or heard of any customers explicitly refer to using WebUI Test Studio for MVC testing, but looking at the MVC overview, it appears that WebUI will work in testing apps created using MVC.
Since the views contain the html markup and content sent to browsers, WebUI can simulate user inputs and interactions, then verifiy expected outputs on the view/UI layer.
Here are some demo
videos listed under WebUI that you can watch and please keep in mind that you can use WebUI in a trial period to further evaluate the product.
the Telerik team