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I used Build & Deploy to install the debug build of my app to my Galaxy Note II running Android 4.1.2 and my Nexus 10 running Android 4.2.2. On my Galaxy Note II, I can then install over top of that the "publish" build and everything upgrades fine. However, if I try to upgrade to the "publish" .apk on my Nexus 10, I get the error "App not installed. An existing package by the same name with a conflicting signature is already installed." I believe this issue stems from the Nexus 10 using the multi-profile feature of Android 4.2.2. In order to get the publish .apk to install, I have to manually uninstall it from BOTH profiles or use "adb uninstall", then I can install the publish .apk. I just wanted to give you a heads up about this relatively minor issue before more devices start using the multi-profile feature of Android 4.2.2+.