Hello Mac P,
we haven't tested this scenario and we can't tell you which will be more performant. The thing with performance is that it should always be measured - I can recommend you to test the both cases. I believe that if you write to DB directly will be faster, but it could expose a problem - if the user closes the browser while the file is still not uploaded successfully you will end up with a partly stored file in DB and it may be a problem for your application.
About the webfarm - if you have multiple SQL servers - yes it will be a problem. If you have a single sql server it should be ok.
All the best,
the Telerik team
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