Hi, 
    In my page, it consists of a ListBox and a GridView, when Selection of ListBox is Changed,  the Columns of GridView also be changed. Different listboxitem have different columns of GridView. I use this way to set the value to binding the different data Source to display: 
            target.DataMemberBinding = source.DataMemberBinding;
            target.Header = source.Header;
            target.DataFormatString = source.DataFormatString;
            target.TextAlignment = source.TextAlignment;
            if (target.DataMemberBinding != null && source.DataMemberBinding != null)
                target.DataMemberBinding.Converter = source.DataMemberBinding.Converter;
            target.IsReadOnly = source.IsReadOnly;
            target.ItemsSource = differentSource;

now, it has a problem, when changing the selection of ListBox, it is so slow to load the new columns. In other words, the page responses slowly.   there are two attachfile. please check it.