Hello Devender Sharma,
I am sorry for the delay responding to you.
1) Yes, WebAii 2.0 runs just fine under 64-bit Windows 7. It doesn't support 64-bit IE, but you probably aren't trying to use that version of IE anyway. The 32-bit version of IE is the default on all versions of Windows.
2) There is no reason we can think of why clicks would not work your configuration. We use that configuration quite regularly as do many of our other customers. Our developers use that very environment as well.
What error do you get? Can you share with us the exception message and stack trace, assuming you are getting one?
the Telerik team