it would seem that you're trying to use our Framework in a way that is not intended. The Framework will allow you to automate an application. In other words there's no reason for you to use the PreMouseClick() event.
You don't need to detect when/where a mouse click occurs. When you automate an application - you determine when and where the click will occur.
Would you please give me some additional information on the automation challenge you're trying to solve.
What do you need to accomplish? Let me know and I will assist to the best of my abilities.
the Telerik team