Thank you for writing.
The API responsible for saving and loading the layout of RadGridView
is not working with the isolated storage. You are allowed to even specify a path and save it to a location of your choice. Please check the documentation for detailed information and examples: http://docs.telerik.com/devtools/winforms/gridview/save-and-load-layout/save-and-load-layout
I noticed, however, that you mention WPF in your post. Please note that you have posted your question in the WinForms forums. In case you are using WPF please specify it as your product and ask your question in the appropriate forum.
I hope this helps. Should you have further questions please do not hesitate to write back.
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Check out the Windows Forms project converter, which aids the conversion process from standard Windows Forms applications written in C# or VB to Telerik UI for WinForms. For more information check out this blog post
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