I have anchor problems too (VS2010, Q3 2009 and Q2 2010 Trial)
What I have is:
Base form that inheriths from RadForm (BaseForm : Radform)
I put RadGroupBox, dock it to bottom. Then I put 2 RadButtons, and put them in bottom right corner (see Step1 - BaseForm.jpg)
Buttons Anchor is set to Botton, Right
I change Modifiers to Protected (for RadGroupBox and for both RadButtons)
This form inherits from Baseform (Form1 : BaseForm)
RadGroupBox and RadButtons appear on 2nd form. It's ok.
I move buttons on 2nd form to left (see Step2 - form1.jpg) and save it.
Now open again Form1 in design and somehow Buttons moved to right (see Step 3 - Form1.jpg)
Save and close it. Open again... Buttons move more to right (see Step 4 - form1.jpg)
I don't know what is wrong. Same thing on "classic" WinForms controls works fine. Nobody is moving.
If you wan't, I have sample solution with whis problem.
Maybe RadButtons don't like my Form, and behind the scens they try to escape :)