In order to use Telerik OpenAccess ORM in web applications/ web sites it is required that the persistent classes are created in a separate Class library project. This project can be then referenced and used by the web application. You will be able to set the database connection while enabling the class library (step 3 of the wizard). You can follow the first 5 steps of this knowledge base article
to understand the process. Hope that helps.
the Telerik team