You're prolly trying to change the built-in settings; you can't.
The first thing you need do is create a new profile by hitting the "New" button. IIRC, when creating my first profile I ad to save it before I could make any changes to it. I think that that is a small bug in the code. However, once you have created a profile, I think you'll find you can modify the settings.
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Stuart
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Deyan Varchev
Telerik team
answered on 30 Mar 2011, 02:39 PM
Hello Annette,
Stuart is 100% right. Code cleaning works under the "profiles" principle. You have to create a new custom profile in order to be able to change what cleaning options. Each profile can have different subset of all code cleaning options to be executed.
This is a new feature that we introduced in our latest release and some small problems can be expected (like the one Stuart points out). We are already working on polishing and improving this for the next release.