Once again, I'm sorry for all the troubles you've got using the controls. Some stuff are not related to the installer though, but to assembly/reference handling of Visual Studio. For example, the switch from .NET Framework 3.5 to .NET Framework 4.0 cannot be handled by the installer.
While we are doing our best to support .NET Framework 2.0, 3.5 and 4.0 alltogether in order to cover the needs of our customers, sometimes all the operations inside the IDE get complicated and take more time to be discovered, analyzed and decent solutions implemented. That's why we do our best to help you guys immediately through our forums and support system.
Having that said, we still do our best to fix any specific problems reported once we have enough details and are able to reproduce it locally.
I want to thank you all for your support on behalf of Telerik. Just don't hesitate to report us the details of the glitches you find with our controls. We are sure we'll find a solution, or at least a workaround.
the Telerik team
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