I have a grid which I tooltipify using tooltipmanager. These controls reside in a UserControl, which is in turn placed in a panel on my page. I ajaxify the panel using RadajaxManager. I am running into the problem of the ToolTipManager's OnAjax Update getting screwed up because I assume this scenario causes nested update panels to be rendered. The reason I ajaxify the panel is because it contains other controls which I would like to update through ajax when a certain button is clicked on the page, and primarily, because I would like a loading image to display over the whole panel and its controls, not just the grid. Now, I have managed to get this to work by exposing the grid and tootipmanager as properties of the usercontrol, and ajaxifying these directly. In this way, I am able to avoide the nested update panels and the tooltipmanager works fine. However, its not exactly the interface I'm looking for. In this case, the loading panel only appears over the grid. I have read some forum posts regarding conditional updating and I'm not sure if that would help in my scenario, or if its possible with RadAjaxManager. Can anyone make any suggestions about how to get tooltipmanager in an ajaxified panel to work properly?